General Clinical Chemistry Analyzers and Accessories
AdipoGen C10-DL-HSL
Chemical. CAS 106983-36-2. Formula C14H25NO3. MW 255.4. Synthetic. N-Decanoyl-DL-homoserine lactone N-C10-HSL is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones AHL are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms.
AdipoGen 7-Dehydrocholesterol
Chemical. CAS 434-16-2. Formula C27H44O. MW 384.64. Synthetic Precursor of cholesterol and vitamin D3. It is reduced to cholesterol by the enzyme 3beta-hydroxysterol-Delta7-reductase DHCR7 in the last step of cholesterol biosynthesis. Mutations in the gene encoding DHCR7 lead to increased levels of 7-DHC and the neurodevelopmental syndrome Smith-Lemli-Opitz syndrome SLOS. 7-DHC is used as a biomarker for SLOS screenings. Inhibits human fibroblast sphingomyelinase. Shown to have cytotoxic effects on melanoma cells. In skin, photolysis of 7-DHC by ultraviolet light produces vitamin D3. UV/Vis lambdamax 271, 282, 293nm.
AdipoGen 7-Diethylamino-3-MD-propyl-CC
Chemical. CAS 160291-54-3. Formula C21H23N3O5. MW 397.42. Synthetic. Thiol-reactive probe for protein labelling.
AdipoGen Chlorferone
Chemical. CAS 6174-86-3. Formula C10H7ClO3. MW 210.61. Synthetic. Major metabolite and hydrolysis product of coumaphos, an organophosphate pesticide. Shown to have acetylcholinesterase and butyrylcholinesterase inhibitor activity and moderate to weak alpha-glucosidase inhibitory and antioxidant scavenging activity. Also used as a building block in the synthesis of fluorogenic substrates for the detection of bacterial beta-Galactosidase.
AdipoGen DCCH
Chemical. CAS 100343-98-4. Formula C14H17N3O3. MW 275.3. Synthetic. Derivatizing agent for carboxylic acid detection. Has also been used for fluorescence detection of monoterpene alcohols.
AdipoGen Cefpodoxime
Chemical. CAS 80210-62-4. Formula C15H17N5O6S2. MW 427.46. Synthetic. Cefpodoxime is a metabolite of cefpodoxime proxetil, an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria MIC90 ranges from 0.015-8 µg/ml. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls.
AdipoGen Cordycepin
Chemical. CAS 73-03-0. Formula C10H13N5O3. MW 251.24. Synthetic. Cordycepin is a nucleoside adenosine analog antibiotic that acts as a polyadenylation inhibitor when converted to 3’-deoxyadenosine triphosphate 3-dATP, which inhibits ATP-dependent DNA and RNA synthesis. Cordycepin has a broad spectrum of biological activities, including anticancer, anti-proliferative, pro-apoptotic, anti-inflammatory and antifungal effects. It was shown to modulate autophagy and NLRP3 inflammasome. Cordycepin has been shown to reduce polyA tail length in mRNA, to activate AMPK kinase, leading to a reduction in mTOR signalling, downregulate ERK/Akt/PI3K/GSK-3beta/beta-catenin signaling pathways. Also useful for the study of messenger RNA transcription.
AdipoGen 1-4-Carboxybutyl-3 7-dmx
Chemical. CAS 38975-44-9. Formula C12H16N4O4. MW 280.28. Synthetic Pentoxifylline PTX metabolite. Can be used as reference material. Showed platelet aggregation in whole blood in vitro. Shown to be more effective than PTX in protecting WC/1 murine fibrosarcoma cells from TNF-alpha cytotoxicity and in inhibiting neutrophil superoxide anion production, degranulation lactoferrin release and surface expression of the beta-2 integrin CD11b/CD18.
AdipoGen 2-Chloro-5-ClMethiazole
Chemical. CAS 105827-91-6. Formula C4H3Cl2NS. MW 168. Synthetic. Intermediate in the preparation of agrochemicals/pesticides.
AdipoGen Clothianidin-d3
Chemical. CAS 1262776-24-8. Formula C6D3H5ClN5O2S. MW 252.7. Clothianidin-d3 is deuterium labelled Clothianidin, which is a neonicotinoid insecticide. Neonicotinoids NNIs are a family of active substances used in plant protection to control harmful insects and also in veterinary medicine. Neonicotinoids act selectively on the insect nicotinic acetylcholine receptors nAChRs, initially stimulating postsynaptic receptors, increasing Na ingress and K egress and then paralyzing nerve conduction, resulting in rapid death. This compound can be used as a reference compound, in the determination of several neonicotinoid insecticides present in bee pollen, using ultra-high performance liquid chromatography UHPLC coupled with mass spectrometry MS.
AdipoGen Cytisine
Chemical. CAS 485-35-8. Formula C11H14N2O. MW 190.2. Synthetic. Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities. Used for smoking cessation. Iron-chelator and hydroxyl radical scavanger. Has antidepressant properties. Used in forensics in novel surface molecular imprinting techniques.
AdipoGen N-Desmethylthiamethoxam
Chemical. CAS 171103-04-1. Formula C7H8ClN5O3S. MW 277.69. Synthetic. Neonicotinoid insecticide. Interacts with insect nicotinic acetylcholine receptors nAChRs, but is about 25 times less potent than thiamethoxam as an insecticide. Shown to be almost as active as the insecticide imidacloprid. Can be used as a reference compound.
AdipoGen Rubpy2mcbpyPF62
Chemical. CAS 136724-83-9. Formula Rubpy2mCbpy PF62. MW 917.59. Intermediate to produce the activated Rubpy2mcbpy-O-Su-esterPF62 ester, suitable for 1D- or 2D-protein gel staining and for acylation of amino acid side chain amines. Used to derivatize polymers and oligonucleotides and for luminescent applications.
AdipoGen QC-107
Chemical. CAS 69352-04-1. Formula C9H10ClIO. MW 296.5. Synthetic. A Hypervalent iodine reagent for oxidation reactions.
AdipoGen 3-Cyano-7-ethoxycoumarin
Chemical. CAS 117620-77-6. Formula C12H9NO3. MW 215.2. Synthetic. Substrate for determination of cytochrom P-450 dependent oxidases about 50-100 times more sensitive than conventional substrate ethoxy-resorufin due to higher turn over rate.