General Clinical Chemistry Analyzers and Accessories
THERMO SCI 3P AIG PARTS & ACCESSORIES TIN DISKS 30 MM SET OF 100
501346835 TIN DISKS 30 MM SET OF 100
Abcam CK869, Actin-related protein 2/3 (Arp2/3) comple x inhibitor, 25MG
MW 394.3 Da, Purity >98%. Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization with bovine Arp2/3 complex (IC₅₀ = 11 μM) and inhibits the formation of actin filament comet tails by Listeriamonocytogenes in infected SKOV3 cells (IC₅₀ = 7 μM) . Does not inhibit budding or fission yeast Arp2/3 complexes.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LMK 235, HDAC inhibitor, 25MG
MW 294.35 Da, Purity >98%. Highly potent and selective HDAC inhibitor. Greater potency for HDAC4 and HDAC5 (IC₅₀ = 11.9 and 4.2 nM, respectively) than other HDAC family members (IC₅₀ values = HDAC1 320 nM, HDAC2 881 nM, HDAC6 55.7 nM, and HDAC8 1278 nM. Demonstrates inhibitor activity in human ovarian cell lines (IC₅₀ =0.49μM) and cisplatin resistant cell lines (IC₅₀ = 0.32μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam G10, STING signaling activator, 5MG
MW 430.9 Da, Purity >98%. G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC₉₀s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Miglustat hydrochloride, 1MG
MW 255.74 Da, Purity >=98%. An inhibitor of the N-linked oligosaccharide processing enzymes α-glucosidase I and II. It inhibits rat testicular enzymes ceramide-glucosyltransferase and beta-glucosidase 2 with IC₅₀ values of 32 and 81 μM respectively. Miglustat is used for the treatment of type 1 Gaucher's disease. It is an inhibitor of HIV replication in vitro. It shows activity against SARS-CoV-2 in vitro with EC₅₀ values in the micromolar range.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CHIR-124, 5MG
MW 419.9 Da, Purity >98%. Novel and potent Chk1 inhibitor (IC₅₀ = 0.3 nM), 2,000-fold more potent than Chk2 (IC₅₀ = 0.7 μM). Also, potently targets other kinases such as FLT3 (IC₅₀ = 5.8 nM), PDGFR (IC₅₀ = 6.6 nM), GSK-3 (IC₅₀ = 23.3 nM) and Fyn (IC₅₀ = 98.8 nM) .
The product is subject to the following: Abcam Restricted Use Statement
Abcam FC 131, C x CR4 activation inhibitor, 10MG
MW 729.8 Da, Purity >95%. FC 131, CXCR4 activation inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen PolyR-3-hydroxybutyric acid
Chemical. CAS 29435-48-1. Formulan. MW 104.1. PHB is a fully biodegradable polyester with optical activity, piezoelectricity, and very good barrier properties. PHB is a partially crystalline material with a high melting temperature and a high degree of crystallinity. PHB is a thermoplastic, belonging to the family of polyhydroxyalkanoate PHAs. It has physical- and mechanical properties comparable to those of isotactic polypropylene iPP. Different bacterial types of microorganisms produce PHB from renewable sources from sugar and molasses as intracellular storage materials. It can be used in applications of drug-loaded medical devices and microspheres as implantable and injectable therapeutic systems in medicine for treatment of various diseases. Besides application of PHB for producing of medical devices and systems of sustained drug delivery, PHB can be used for production of systems for controlled release of activators or inhibitors of enzymes. The use of these sys
Abcam CCT128930, 10MG
MW 341.8 Da, Purity =98%. Potent and selective AKT2 inhibitor (IC50= 6 nM) with selectivity greater than 28-fold and 20-fold over PKA kinase (IC50= 168 nM) and p70S6K (IC50= 120 nM), respectively.
The product is subject to the following: Abcam Restricted Use Statement
Alkali Scientific 5mL False Bottom Analyzer Tubes with Threads, 16×97mm, Polypropylene (PP), Amber, 5000/Case
These 5mL False Bottom Analyzer Tubes (16×97mm) with Threads are designed for use in high volume chemistry and diagnostic analyzers. They are compatible with popular analyzers from Hitachi, Olympus, Corning, Ortho, Kodak, Beckman, IA, Tosoh, Vitros and more. Manufactured from high grade polypropylene (PP), these tubes offer excellent chemical resistance and can be safely autoclaved at 121 °C. With a conical false bottom for reduced dead volume and accurate sample retrieval, these tubes are ideal for serum collection, sample transport, or storage. Available in natural or amber options to protect light sensitive samples, they are self standing and designed to fit most universal analyzer racks, including AU 5000 systems. Features: 5mL nominal capacity, 16×97 mm Compatible with Hitachi, Olympus, Corning, Ortho, Beckman, Vitros, Tosoh, and other analyzers Made of chemical resistant polypropylene; autoclavable at 121 °C Available in natural or amber PP for light sensitific.
Abcam Elevenostat, 1MG
MW 315.32 g/mol, Purity >=95%. A small molecule hydroxamic acid derivative that acts as a HDAC11-selective inhibitor. Reporter assays using a luciferase-linked Foxp3 promoter shows that HDAC11 decreases the signal driven by NFκB/p65, alone or in the presence of transfected Foxp3, and impairs luciferase activity driven by p65, Foxp3 and the HAT enzyme, p300. The inhibitory effects of HDAC11 at the Foxp3 promoter are reversed by Elevenostat (JB3-22), (IC₅₀ 0.235 μM). Elevenostat also partially reverses the inhibitory effect of HDAC11 on p300-induced Foxp3 acetylation at lysine 31 consistent with the ability of HDAC11 to directly regulate acetylation of Foxp3.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Acetazolamide, carbonic anhydrase inhibitor, 5MG
MW 222.3 Da, Purity >98%. Non-specific carbonic anhydrase inhibitor with diverse physiological effects that are cell and tissue specific. Heterocyclic primary sulfonamide.
The product is subject to the following: Abcam Restricted Use Statement